Glaucoma kills neurons in the optic nerve and causes blindness. Repairing neurons that send visual information from the eye to the brain is a challenge for two reasons: neurons don’t spontaneously regenerate after injury, and proteins in the optic nerve can impede their growth. Recent discoveries have identified ways to trigger regeneration in neurons, but inhibitory proteins still prevent them from reaching the brain. My PhD work targeted these proteins by digesting and neutralizing their inhibitory sugar chains with an enzyme called arylsulfatase B. By combining this treatment with a regeneration trigger, we hope to enable neurons to grow farther, connect with the brain, and ultimately restore vision.